semaphorins

semaphorins
Family of proteins that mediate neuronal guidance by inhibiting nerve growth cone movement. Both transmembrane and secreted proteins are included and many domains of the proteins are highly conserved between invertebrates and vertebrates. Most are around 750 residues with a conserved "sema" domain of up to 500 residues extracellularly with a single immunoglobulin C2-type domain C-terminally to this. Collapsin, responsible for the collapse of nerve growth cones of chick sensory neurites in culture following contact with retinal axons was one of the first semaphorins described.

Dictionary of molecular biology. 2004.

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  • Semaphorin — Semaphorins are a class of secreted and membrane proteins that act as axonal growth cone guidance molecules. They primarily act as short range inhibitory signals and signal through multimeric receptor complexes. They are usually cues to deflect… …   Wikipedia

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  • SEMA4A — Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A, also known as SEMA4A, is a human gene.cite web | title = Entrez Gene: SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane… …   Wikipedia

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